Вплив препарату «Каплаэстрол+OV» на показники прооксидатно-антиоксилантного статусу корів за гонадопатій

Abstract

У статті наведена інформація про вплив препарату «Каплаестрол+ОV» на деякі показники концентрації похідних вільнорадикальних окислів та статусу антиоксидантного захисту у коре за оваріодистрофії, гіпогонадизму та діорганної патології (ендометритез»гіполютеоліз).

В статье приведена информация о влиянии препарата на основе нанобиоматериалов "Каплаэстрол+О\/" на некоторые показатели концентрации производных свободнорадикальных окислов и статуса антиоксидантной защиты у коров при овариодистрофии, гипогонадизме и диорганной патологии (зндометрите»гиполютеолиз).

Situational increase in the concentration of free oxide in the body for a reduction of antioxidant defense is accompanied by the development of pathological processes. One of the major cell damage by free radicals is the destruction of the fatty acids that make up cell membranes (lipid peroxidation). Peroxidation of lipids of biological membranes causes a disturbance of the barrier function and reduces the enzymatic activity; disintegrates receptor binding and vesicular transport. This leads to disruption of cellular activity, accelerated apoptosis degeneration, necrobiosis, atrophy and necrosis. The damaging effect of oxygen radicals in the cell antioxidant defense system opposed., protection function is performed by enzymes - superoxide dismutase, catalase, glutathione reductase, and low molecular weight non-enzymatic antioxidants (carotenoids, tocopherol), water soluble vitamins (ascorbic acid). Thus, the oxidation of lipid structures underlying the development of many diseases, including pathologies animal reproductive organs. Among the disorders of the reproductive function in cows is quite common gonadopathy such as gonadodystrophy, hypogonadism and hypoluteolisis on background endometritis (diorgan pathology). The emergence and development of ovarian pathologies cows hypothetically can be supplemented by the existence of violations, failures in the prooxidant-antioxidant system, as the basis of these pathologies is a violation tropism, of complex mechanisms for metabolism and preserve cell structure and ovarian tissue. To determine the concentration of free oxide derivatives and antioxidant protection status in cows with gonads pathology (ovariodystrophy, hypogonadism and diorgan pathology) presents the materials the article. It is set that for cows after application of preparation of "Caplaestrol+OV" after gonads pathologys, after reparation of ovaries in comparing to the animals to treatment a concentration of malonic dialdehyde in the red corpuscles of blood was for certain diminished on 9,97-16,6 mkMol / |, catalase is megascopic — оп 12,39-28,2 mkMol /Н2О2/ |-min, reduced glutathione - on 0,77 - 1 mkMol Л.