Please use this identifier to cite or link to this item: https://repo.btu.kharkov.ua//handle/123456789/57284
Title: Diagnosis and treatment of hyperthyroidism in cats in condition of farm and pet clinic (Israel)
Authors: Khatib, Atalla
metadata.dc.contributor.advisor: Sobakar, Yu.
metadata.dc.contributor.affiliation: Державний біотехнологічний університет, Head of internal diseases and clinical diagnosis of animals department
Keywords: hyperthyroidism;cats;thyroxine;diagnosis;treatment scheme;thiamazole;carbimazole
Issue Date: 2024
Publisher: Kharkiv: DBTU
Citation: Khatib Atalla. Diagnosis and treatment of hyperthyroidism in cats in condition of farm and pet clinic (Israel): master's qualification work: spec. 211 Veterinary medicine; of science driver Yu. Sobakar. Kharkiv: DBTU, 2024. 69 p.
Abstract: Relevance of the topic of the qualification work. The purpose of the qualification work. The aim of the study was to find informative parameters for diagnosing hyperthyroidism in cats. After diagnosis was made, treatment with the use of antithyroid drugs was prescribed (Carbimasol for the control group of cats and Tiamazol for the experimental group of animals). Task: The aim of the study was to diagnose hyperthyroidism in cats using next parameters: anamnestic data, clinical examination, ultrasound thyroid examination, hematological and biochemical studies determination of total serum thyroxine (T4). And estimate efficiency of treatment of cats with thyrotoxicosis. Object of study. The object of the study were 10 cats with clinical sign of thyrotoxicosis Subject of study. Hyperthyroidism in cats. Theoretical and practical significance of the obtained results. The main symptoms and indicators for diagnosis are: increasing the size and structure of the thyroid gland (the thyroid gland was increased in size bilaterally in 80 % of cats and unilateral in 20 % of animals, 241,1 mm3 to 493,7 mm3. And pathognomonic parameter for diagnosis hyperthyreosis in cats was increase in the level of total T4 in of blood: 90,20±1,15 and 97,90±1,36 nmol/l. Normal values of T 4 -10-60 nmol/l. Cats with subnormal T4 values are almost euthyroid sick or overtreated for hyperthyroidism. Older cats with consistent clinical signs and T4 concentration in gray zone 30-60 nmol/l may have early hyperthyroidism or a concurrent non-thyroidal illness. Hyperthyroidism may be confirmed in these cats by adding on free T4 or by performing a T3 suppression test.
URI: https://repo.btu.kharkov.ua//handle/123456789/57284
metadata.dcterms.references: 1. Feldman E.C., Nelson R.W. Feline hyperthyroidism (thyrotoxicosis). In: Feldman EC, Nelson RW, editors. Canine and Feline Endocrinology and Reproduction. 3rd ed. St Louis, MO, USA: Elsevier Saunders; 2004. 2. Nguyen L.Q., Arseven O.K., Gerber H., Stein B.S., Jameson J.L., Kopp P. Cloning of the cat TSH receptor and evidence against an autoimmune etiology of feline hyperthyroidism. Endocrinology. 2002; 143(2): 395–402. 3. Martin K.M., Rossing M.A., Ryland L.M., DiGiacomo R.F., Freitag W.A. Evaluation of dietary and environmental risk factors for hyperthyroidism in cats. Journal of American Veterinary Medical Association. 2000; 217(6): 853–856. 4. Edinboro C.H., Scott-Moncrieff J.C., Janovitz E., Thacker H.L., Glickman L.T. Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats. Journal of American Veterinary Medical Association. 2004; 224(6): 879–886. 5. Olczak J., Jones B.R., Pfeiffer D.U., Squires R.A., Morris R.S., Markwell P.J. Multivariate analysis of risk factors for feline hyperthyroidism in New Zealand. New Zealand VeterinaryJournal. 2004 ; 53(1): 53–58. 6. Peterson M.E., Ward C.R. Ethio Pathologic findings of hyperthyroidism cats. Veterinary Clinical Northern American Small Animal Practice. 2007; 37(4): 633–645. 7. Baral R, Peterson ME. Thyroid gland disorders. In: Little SE, editor. The Cat: Clinical Medicine and Management. Philadelphia, PA, USA: Elsevier Saunders; 2012. 8. Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system. The New England Journal of medicine. 2001; 344(7): 501–509. 9. Syme H.M. Cardiovascular and renal manifestations of hyperthyroidism. Veterinary Clinical Northern American Small Animal Practice. 2007; 37(4): 723–743. 10. Marrow L.D., Adams V.J., Elliott J., et al. Hypertension in hyperthyroid cats: prevalence, incidence, and predictors of its development. Journal Veterinary Internal Medicine. 2009; 23(3): 699. 11. Williams T.L., Peak K.J., Brodbelt D., et al. Survival and the development of azotemia after treatment of hyperthyroid cats. Journal Veterinary Internal Medicine. 2010; 24(4): 863–869. 12. Mooney CT. Hyperthyroidism. In: Ettinger SJ, Feldman EC, editors. Textbook of Veterinary Internal Medicine. 7th ed. St Louis, MO, USA: Elsevier Saunders; 2010. 13. Upadhyay G., Singh R., Kumar A. Severe hyperthyroidism induces mitochondria-mediated apoptosis in rat liver. Hepatology. 2004; 39(4): 1120–1130. 14. Andican G., Gelisgen R., Civelek S., et al. Oxidative damage to nuclear DNA in hyperthyroid rat liver: inability of vitamin C to prevent the damage. Journal Toxicology Environmental Health. 2004; 67(5): 413–420. 15. Foster D.J., Thoday K.L. Tissue sources of serum alkaline phosphatase in 34 hyperthyroid cats: a qualitative and quantitative study. Research Veterinary Science. 2000; 68(1): 89–94. 16. Berent A.C., Drobatz K.J., Ziemer L. Liver function in cats with hyperthyroidism before and after 131I therapy. Journal Veterinary Internal Medicine. 2007; 21(6): 1217–1223. 17. van Hoek I., Lefebvre H.P., Peremans K., et al. Short- and long-term follow up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine. Domest Anim Endocrinol. 2009; 36(1): 45–56. 18. Mayer-Poenne B., Goldstein R.E., Erb H.N. Urinary tract infections in cats with hyperthyroidism, diabetes mellitus and chronic kidney disease. Journal Feline Medical Surgery. 2007; 9(2):124–132. 19. Peterson M.E., Melian C., Nichols R. Measurement of serum concentrations of free thyroxine, total thyroxine, and total triiodothyronine in cats with hyperthyroidism and cats with nonthyroidal disease. Journal of American Veterinary Medical Association. 2001; 218(4): 529–536. 20. Peterson M.E. Diagnostic testing for hyperthyroidism in cats: more than just T4 . Journal of Feline Medical Surgery. 2013; 15(9): 765–777. 21. Lurye J.C., Behrend E.N., Kemppainen R.J. Evaluation of an in-house enzyme-linked immunosorbent assay for the quantitative measurement of serum total thyroxine concentration in dogs and cats. Journal of American Veterinary Medical Association. 2002; 221(2): 243–249. 22. Kemppainen R.J., Birchfield J.R. Measurement of total thyroxine concentration in serum from dogs and cats by use of various methods. American Journal of Veterinary Research. 2006; 67(2): 259–265. 23. Wakeling J., Moore K., Elliot J., Syme S.H. Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. Journal of Small Animal Practice. 2008; 49(6): 287–294. 24. Daminet S., Kooistra H.S., Fracassi F., et al. Best practice for the pharmacological management of hyperthyroid cats with antithyroid drugs. Journal of Small Animal Practice. 2014; 55(1): 4–13. 25. Trepanier L.A., Hoffman S.B., Kroll M., Rodan I., Challoner L. Efficacy and safety of once versus twice daily administration of methimazole in cats with hyperthyroidism. Journal of American Veterinary Medical Association. 2003; 222(7): 954–958. 26. Rutland B.E., Nachreiner R.F., Kruger J.M. Optimal testing for thyroid hormone concentration after treatment with methimazole in healthy and hyperthyroid cats. Journal of Veterinary Internal Medicine. 2009; 23(5): 1025–1030. 27. Becker T.J., Graves T.K., Kruger J.M., Braselton W.E., Nachreiner R.F. Effects of methimazole on renal function in cats with hyperthyroidism. Journal of American Animal Hospital Association. 2000; 36(3): 215–223. 28. Boag A.K., Neiger R., Slater L., Stevens K.B., Haller M., Church D.B. Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine. Vet Rec. 2007; 161(21): 711–715. 29. Riensche M.R., Graves T.K., Schaeffer D.J. An investigation of predictors of renal insufficiency following treatment of hyperthyroidism in cats. Journal of Feline Medical Surgery. 2008; 10(2): 160–166. 30. Lapointe C., Bélanger M.C., Dunn M., Moreau M., Bedard C. N-acetylβ-D glucosaminidase index as an early biomarker for chronic kidney disease in cats with hyperthyroidism. Journal of Veterinary Internal Medicine. 2008; 22(5): 1103–1110. 31. Milner R.J., Channell C.D., Levy J.K. Survival times for cats with hyperthyroidism treated with iodine 131, methimazole or both: 167 cases (1996–2003). J Am Vet Med Assoc. 2006; 228(4): 559–563. 32. Hoffman S., Yoder A., Trepanier L. Bioavailability of transdermal methimazole in a pluronic lecithin organogel (PLO) in healthy cats. Journal of Veterinary Pharmacological Therapy. 2002; 25(3): 189–193. 33. Hoffmann G., Marks S., Taboada J., Rodan I., Challoner L. Transdermal methimazole treatment in cats with hyperthyroidism. Journal of Feline Medical Surgery. 2003; 5(2): 77–82. 34. Sartor L.L., Trepanier L.A., Kroll M.M., et al. Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. Journal of Veterinary Internal Medicine. 2004; 18(5): 651–655. 35. Hill K.E., Gieseg M.A., Kingsbury D, Lopez-Villabolos N., Bridges J., Chambers P. The efficacy and safety of a novel lipophilic formulation of methimazole for the once daily transdermal treatment of cats with hyperthyroidism. Journal of Veterinary Internal Medicine. 2011; 25(6):1357–1365. 36. Boretti F.S., Sieber-Ruckstuhl N.S., Schafer S., et al. Duration of T4 suppression in hyperthyroid cats treated once and twice daily with transdermal methimazole. Journal of Veterinary Internal Medicine. 2013; 27(2): 377–381. 37. Hill’s Pet Nutrition Inc, Guidelines for management of feline hyperthyroidism, copyright 2012. 38. Melendez L.D., Yamka R.M., Forrester S.D., et al. Titration of dietary iodine for reducing serum thyroxine concentrations in newly diagnosed hyperthyroid cats. Journal of Veterinary Internal Medicine. 2011; 25(4): 683. 39. Yu S., Wedekind P.A., Burris D.S., et al. Controlled level of dietary iodine normalizes serum total thyroxine in cats with naturally occurring hyperthyroidism. Journal of Veterinary Internal Medicine. 2011; 25(4): 683–684. 40. Peterson M. Hyperthyroidism in cats: considering the impact of treatment modality on quality of life for cats and their owners. Veterinary Clinical Northern American Small Animal Practice. 2020; 50(5): 1065-1084. 41. Trepanier L. Medical management of hyperthyroidism. Clinical Technical Small Animal Practice. 2006; 21(1): 22-28. 42. Forrester S., Towell T., Shenoy, K. Nutritional management of feline hyperthyroidism. 2012; Conference Proceedings of the Veterinary Medical Association, 130th Annual Meeting, Iowa: p.87-91 43. Higgs P., Murray J., Hibbert A. Medical management and monitoring of the hyperthyroid cat: a survey of UK general practitioners. Journal of Feline Medical Surgery. 2014, 16(10): 788-795. 44. Pittari J., Rodan I., Beekma G., Gunn-Moore D., Polzin D., Taboada J., Tuzio H., Zoran D. American association of feline practitioners. Senior care guidelines. Journal of Feline Medical Surgery, 2009. 11(9): 763-778.
Appears in Collections:211 - "Ветеринарна медицина" (Магістри)

Files in This Item:
File Description SizeFormat 
2024_211_13m-14-EN_Khatib_Atalla.pdf
  Restricted Access
1.07 MBAdobe PDFView/Open Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.