Антигельмінтна ефективність препаратів за експериментального райєтинозу курей

Abstract

У статті наведено дані щодо порівняльної оцінки ефективності альбендазолу ультра 10 %, бровадазолу та розробленого препарату для лікування цестодозів птиці. За експериментального райєтинозу курей екстенс- та інтенсефективність розробленого препарату для лікування цестодозів курей на 14 добу склала 100 %. Екстенсефективність бровадазолу склала 63,6 % при інтенсефективності 69,0 %, а альбендазолу ультра 10 % ‒ 54,5 % та 66,4 % відповідно.

Tape helminths belonging to the genus Raillietina are the most common bird parasites in the world. R. echinobothrida (Mégnin, 1880) is the most important species in terms of prevalence and pathogenicity, especially in domestic chickens (Gallus domesticus Linnaeus, 1758). The control measures against helminthiasis consists mainly of deworming in a timely manner and according to certain schemes. For group deworming, the vast majority of domestic antiparasitic drugs are made primarily on the basis of 5-6 active substances: albendazole, fenbendazole, levamisole, pyrantel, ivermectin, clozantel. Despite the fact that there are a number of commercial anthelmintics for the treatment of helminthiasis, including cestodoses, most of them lead to an addictive organism that prompts the search for alternative drugs and means of control. The aim of the work was to experimentally reproduce raytinosis in chickens and to test the anthelmintic effectiveness of albendazole ultra 10%, brovadazole and a developed drug for the treatment of cestodoses in birds. Before treatment, the defeat of chickens from all groups of R. echinobothrida was from 62.2±1.2 to 64.1±0.9 eggs in 1 g of feces. After treatment of the chickens of the first experimental group with albendazole, the est efficiency index on the 7th day was 45.4 %, on the 14th and 21st day - 54.5 % and on the 30th day ‒ 45.4 %. The intensity indicator was 56.9 %, 64.3 %, 66.4 % and 58.7 %, respectively. In the second experimental group, after the use of Brovadazole, the extensivity on the 7th day was 36.3 %, on the 14th day ‒ 54.5 %, on the 21st and 30th days ‒ 63.6 % with an intensity efficiency of 49.9 %, 61.6 %, 69,0 % and 68.5 %, respectively. The best indicators of therapeutic efficacy were obtained in the third experimental group of chickens after using the developed drug for the treatment of poultry cestodoses. Efficiency of the drug on the 7th day was 80.2%, on the 14th, 21st and 30th day ‒ 100 %. Intensity on day 7 was 81.8 %, and subsequently 100 %. In the control group, the bird remained invasive during the experiment. Thus, with experimental raietinosis, the effectiveness of the developed drug for the treatment of bird cestodoses on day 14 was 100 %. The effectiveness of brovadazole was 63.6 %, and albendazole ultra 10 % was 54.5 %.