Генетический контроль спонтанного мутирования при старении у Drosophila melanogaster Meig.

Abstract

In this work it was carried out the analysis of the age-changes of the genetic loads in inbrid lines of the straight аnd reciprocal hybrids оf D. melanogaster was carried out, which showed the heterosis effect оn the life duration. The recessive lethal mutations were detected in chromosom 2 т 14-days’ age imago both in inbred lines and in hybrids. For all this, the share of supervital mutations which increase viability decreases in imago оf the inbred lines by 15-17% аnd increases in the hybrids by 17-18%. The aging of reproductive individuals is accompanied by a considerable increase in the dominant lethal mutations rate only in inbred lines by 9-34%. The increase of the dominant lethal mutations rate when aging occurs in the gametes of both males and females. Correlations between the mutations rate in the aging heterosis hybrids and their longer lifespan were found.