Випадок успішного застосування аутологічних факторів росту на перебіг порушеного репаративного остеогенезу при переломі кісток передпліччя у кішки

Abstract

Лікування переломів трубчатих кісток спрямовано на стабільну фіксацію, відновлення рухів та опороздатність кінцівки. Це не завжди дає позитивний результат у разі порушення процесів репаративного остеогенезу. Застосування біологічно активних речовин (аутологічних факторів росту) поряд з використанням механічних факторів надійної іммобілізації уламків (апарат зовнішньої фіксації) при загоєнні перелому кісток передпліччя, створює сприятливі умови для перебігу репаративного остеогенезу та формування кісткової мозолі у тварин.

Лечение переломов трубчатых костей направлено на стабильную фиксацию, возобновление движения и опорной способности конечности. Это не всегда дает позитивный результат при нарушении репаративного остеогенеза. Использование биологически активных веществ (автологических факторов роста) совместно с использованием механических факторов надежной иммобилизации осколков (аппарат наружной фиксации) при заживлении перелома костей предплечья, создает благоприятные условия для течения репаративного остеогенеза и формирования костной мозоли у животных.

It is Known that violations of the processes of reparative regeneration at treatment of the fractures of tubular bones occupy the leading position in the structure of damages of the musculoskeletal system. In spite of the various suggestions in treatment of fractures of tubular bones they are oriented for the stable fixing, proceeding in motions and supporting the ability of the limbs. But, unfortunately, at the stage of treatment of the bones fractures facilities that influence directly on cicatrization of the fracture are seldom in use, it means that the conditions for optimization of motion of reparative osteogenesis and osteotylus formation are not being created. We consider that it is necessary to influence on cicatrization of the fracture not only using the mechanical factors (plates, device of external fixing, rod device, spokes), but also using biologically active substances (growth factors, cytokines). It is known that the main supplier of growth factors in mammals, able to stimulate osteogenesis, is a platelet concentrate. The main sources of platelets are traditionally rich in platelets plasma and platelet-rich fibrin gel. However, unfortunately, platelet concentrate, as an autological stimulator, in a case of bone tissue damage is not used in the orthopedic practice of veterinary medicine of Ukraine. For the first time in Ukrainian veterinary practice, іп the case of violation of the processes of саt's reparative osteogenesis, we have done surgical intervention with application of external fixation device and the simultaneous use of platelet-rich fibrin gel, that was injected through the incision in the fracture area, and after that the wound was sutured. On the 10th day after surgical intervention we stimulated osteogenesis with autologous plasma rich in platelets, that was injected with a sterile syringe into the area of the forearm bone fracture. Recommended inspection was done on the 3rd and 8th days after surgery. After the osteosynthesis of forearm bones was done with the simultaneous use of autologous growth factors we observed a significant reduction of edema in the area of surgery on the 3rd day, that obviously occured due to the release from platelets a significant amount of growth factors. On the 8th day, during removal of the sutures, we noted the complete absence of edema. According to the words of the animal owner, there was a significant improvement in appetite and physical activity of the animal. After the local double injection of growth factors x-ray of the fracture area was done. When analyzing the radiographs it was observed the formation of callus. Thus, the animal was active and stood completely on the injured limb. So, the use of biologically active substances (growth factors) along with the mechanical factors (external fixation device) in the healing of forearm bone fractures, creates effective conditions to optimize the course of reparative osteogenesis and callus formation.