Апитерапия при актиномикозе

Abstract

Прополис как продукт пчеловодства имеет выраженный иммуностимулирующий эффект при актиномикозе крупного рогатого скота при парэнтеральном введении. Эффективнее оказалось местное применение прополиса путем циркулярного обкалывания актиномикомы и промывания гнойных фокусов через открытые свищи актиномикозной гранулемь.

Прополіс як продукт бджільництва має виражений імуностимулюючий ефект при актиномікозі великої рогатої худоби при парентеральному введені. Ефективніше виявилося місцеве застосування прополісу шляхом циркулярного введення навколо актиномікози та промивання гнійних фокусів через відкриті свищі актиномікозної гранулеми.

Actinomycosis is а chronic, opportunistic, infectious disease characterized by the formation of actinomycom in different tissues and organs. Methods for the treatment of actinomycosis with the use of broad-spectrum antibiotics, iodine supplements are not very effective, require a long period of use and do not always provide the expected result. Therefore there is a need for a qualitatively new approach to the treatment of this disease. When choosing immunostimulatory drugs, our attention was drawn to the bee product - propolis. Materials and methods. In the study was studied immunostimulatory properties of water-alcohol solution of propolis for the treatment of actinomycosis of cattle. Was formed two groups of animals on 5 goals on the principle of analogues. In the first group was conducted having a circular aktinomicosis in a circle with the distance between shots in 5 - 7 cm were Injected at the 1 - 1.5 ml, in addition, in the presence of a fistula with a long needle or catheter it injected propolis extract to effective washing. Injection and washing was performed three times with an interval of 5 days. The second group was left intact and served as control. The results of the study. During the inspection of the affected animals revealed massive granulomas, which were localized mainly in the head and upper neck of the animal, extending from the lower part of the head a third and sometimes half of the neck. The granulomas had a monolithic appearance, and has reached a considerable thickness. Analysis of the epizootic situation in the economy and the results of the study allow us to conclude that the reason for such manifestations of actinomycosis could be a decrease in natural resistance of the organism, the presence of a failure of the immune defense and lower the protective reactions of the organism. For this reason, granulomas freely arose as the spread of the pathogen in the tissues of the body. About the content of immunoglobulins in the blood serum lumpy judged for the results of a ring test of precipitation with PEG 6000. The best indicators of levels of immunoglobulins had the animals of the first group, where the extract of propolis applied topically by injecting actinomycin in a circle, all animals showed improved levels of immunoglobulins. In the control animals of the 2nd group of indicators remained unchanged, with the exception of one animal, whose figure has increased. The obtained results indicate a decrease in the immune status of the animals of the control group. Animals of the 1st group when having actinomycin marked improvement in the immune status in the absence of immunodeficient animals. As a result of clinical observation of experimental animals of the 1st experimental group was observed a decrease in size and compaction of the treated tumors with the termination of purulent discharge and the closure of the holes at the three animals. Conclusions: 1. Propolis as bee product has broad spectrum activity and immunostimulating effect, which sufficiently manifested in the treatment of actinomycosis of cattle. 2. Water-alcohol extract of propolis has a distinct immunostimulatory effect in actinomycosis of cattle for parenteral administration. 3. More effective was a local application of propolis by circular injecting aktinomicose and washing of the purulent foci through the open fistula actinomycosis granulomas.