Исследование мутагенной активности ряда анионных азокрасителей в тест-системе "Drosophila"

Abstract

For the first time the mutagenic activity of a new class of azo dyes - anion azo dyes - has been «Drosophila» test system. The received data testify to the fact that for anion azo dyes the induction gene mutation is most typical. The increase in frequency of dominant lethal mutation was registered on a line with a reparation broken after replication. It has been established that with the increase in number of azogroups in the molecule the mutagenic activity of azo dyes is reduced. Comparing the results received earlier in the similar test by Ames we can make a conclusion about the priority of research on Drosophila melanogaster.